1st: mute!
2nd: more permanent upgrades. once you got 100k weapons, its over with upgrades.
3rd more vision. you cant see almost anything below your position. So the best position would be the lowest edge, where you got some room to cruise.
4th DONT let creeps summon at or close to your position! Or at least mark the positions where the creeps will appear.
really easy game, once you've got enough weapons to slow your PC down (100 one, lots of bullets), you just need to move constantly in circles around the area with wormholes. The game seems to have a priority to render your bullets and wormholes wont summon almost anything.
Tip2: use turrets only, put them all around you so they shoot down homing missiles. upgrade the front turrets is enough, use full speed for max damage output.