I see people repeatedly telling what the "best combo" is. They're full of shit. Use whatever works for you. The only Advice I have is: Don't double class.
That being said, I love this game. It's the first one but better, sweet.
The survival mode is kinda boring. I just got to lv 25 and quit, because I got there even though I forgot to equip my skills, so I can't image losing before level 50? And probably not till 150+ if I had my skills. I think survival would be cooler if you could get new items, or if it was a lot harder.
The only gripe I have with the game is the extreme repetition. I'm really happy to see that you can make the game extremely hard now, as that will be a fun little game to play.
 "Sonny")
 "Monsters' Den: Book of Dread")